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Some cancer types, such as acute leukemia and bone marrow cancer multiple myeloma for example, cannot be treated without antibiotics. Antibiotic resistant bacteria will set cancer treatment back for decades, while the incidence of cancer cases will continue to rise in the years to come.
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For the patients, this may mean higher mortality, more difficult and more expensive treatment, and many side and late effects. Many treatment options will disappear entirely. Bacterial infection is one of the most common complications among cancer patients. A weakened immune system and infections can prove life-threatening for patients with serious diseases. After surgery, many patients require antibiotics to treat infected wounds. Chem Biol. Systemic Therapy. Philadelphia, Pa: Elsevier Churchill Livingstone; Gullatte MM, Gaddis J.
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Chemotherapy & Antibiotics
For reprint requests, please see our Content Usage Policy. How Chemotherapy Drugs Work More than chemotherapy or chemo drugs are used to treat cancer — either alone or in combination with other drugs or treatments. Chemotherapy works with the cell cycle Chemotherapy drugs target cells at different phases of the process of forming new cells, called the cell cycle. Types of chemo drugs Chemo drugs can be grouped by how they work, their chemical structure, and their relationships to other drugs.
Alkylating agents Alkylating agents keep the cell from reproducing by damaging its DNA. Anti-tumor antibiotics that are not anthracyclines include: Actinomycin-D Bleomycin Mitomycin-C Mitoxantrone also acts as a topoisomerase II inhibitor, see below Topoisomerase inhibitors These drugs interfere with enzymes called topoisomerases, which help separate the strands of DNA so they can be copied.
Topoisomerase inhibitors are grouped according to which type of enzyme they affect: Topoisomerase I inhibitors include: Topotecan Irinotecan CPT Mitoxantrone also acts as an anti-tumor antibiotic Topoisomerase II inhibitors can increase the risk of a second cancer — acute myelogenous leukemia AML — as early as 2 to 3 years after the drug is given. Mitotic inhibitors Mitotic inhibitors are compounds derived from natural products, such as plants. Examples of mitotic inhibitors include: Docetaxel Estramustine Ixabepilone Paclitaxel Vinblastine Vincristine Vinorelbine They are used to treat many different types of cancer including breast, lung, myelomas, lymphomas, and leukemias.
Corticosteroids Corticosteroids, often simply called steroids, are natural hormones and hormone-like drugs that are useful in the treatment of many types of cancer, as well as other illnesses.
Antibiotics greatly reduce effectiveness of immunotherapy for cancer – study
Other chemotherapy drugs Some chemotherapy drugs act in slightly different ways and do not fit well into any of the other categories. Targeted therapies Targeted therapies attack cancer cells more specifically than traditional chemotherapy drugs. Differentiating agents These drugs act on the cancer cells to make them mature into normal cells. Hormone therapy Drugs in this category are sex hormones, or hormone-like drugs, that are used to slow the growth of breast, prostate, and endometrial uterine cancers, which normally grow in response to natural sex hormones in the body.
Types of Chemotherapy
Immunotherapy Some treatments are given to people with cancer to help their immune systems recognize and attack cancer cells. Antibiotics and Chemotherapy Current Topics.
Editors view affiliations R. Front Matter Pages i-xi. The chemotherapy of infective endocarditis. Pages Prophylactic antimicrobial drug therapy.
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The cephalosporin group of antibiotics. Anaerobic infections and their treatment.